Increasing Arctic marine use is driven primarily by natural resource development and greater marine access throughout the Arctic Ocean created by profound sea ice retreat. Significant management measures to enhance protection of Arctic people and the marine environment are emerging, including the development of marine protected areas (MPAs), which may be effective and valuable tools. MPAs have been established by individual Arctic coastal states within their respective national jurisdictions; however, a pan-Arctic network of MPAs has yet to be established despite Arctic Council deliberations. This overview focusses on those MPAs that can be designated by the International Maritime Organization and by international instrument or treaty to respond to increasing Arctic marine operations and shipping. Key challenges remain in the Arctic to the introduction of select MPAs and development of a circumpolar network of MPAs in response to greater marine use: the variability of sea ice; the rights and concerns of indigenous people; a lack of marine infrastructure; application to the Central Arctic Ocean; establishing effective monitoring; and compliance and enforcement in remote polar seas. Robust bilateral and multilateral cooperation will be necessary not only to establish effective MPAs but also to sustain them for the long term. Reducing the large Arctic marine infrastructure gap will be a key requirement to achieve effective MPA management and attain critical conservation goals.